Objective

To study the effect of phenylacetic acid and fufurylamine (equimolar solutions) in benzene on the solubility of the Ugi product UC176C

Procedure

Results

Spreadsheet ONSCExp147

[Report SAMS measured concentration of amine, acid, imine and Ugi product in each sample JCB]

Discussion

[Are these results consistent with measurements from previous experiments? JCB]

Conclusion

[You have all the data - conclude this JCB]

Log

2009-11-09
17:45 To 200uL of solution 146A (0.999M), containing 0.199 mmol of phenylacetic acid; added fufurylamine (0.199mmol, 17.7uL), vortexed the solution and then added the Ugi product UCExp251-1C, vortexed again and ensured atleast some of the Ugi product remained undissolved. This solution is labeled ONSCExp147-1;
17:50 To 200uL of solution 146B (0.397M) containing 0.0794 mmol of phenylacetic acid; added fufurylamine (0.0.0794mmol, 7.01uL), vortexed the solution and then added the Ugi product UCExp251-1C, vortexed again and ensured atleast some of the Ugi product remained undissolved. This solution is labeled ONSCExp147-2
17:55 To 200uL of solution 146C (0.301M) containing 0.0602 mmol of phenylacetic acid; added furfurylamine (0.0602mmol, 5.32), vortexed the solution and then added the Ugi product UCExp251-1C, vortexed again and ensured atleast some of the Ugi product remained undissolved. This solution is labeled ONSCExp147-3
18:00 To 200uL of solution 146D (0.198M) containing 0.0396 mmol of phenylacetic acid; added fufurylamine (0.0396mmol, 3.5uL), vortexed the solution and then added the Ugi product UCExp251-1C, vortexed again to ensured atleast some of the Ugi product remained undissolved. This solution is labeled ONSCExp147-4
18:05 To 200uL of solution 146E (0.103M) containing 0.0206mmol of phenylacetic acid added fufurylamine (0.0206mmol, 1.82uL), vortexed the solution and then added the Ugi product UCExp251-1C, vortexed again and ensured atleast some of the Ugi product remained undissolved. This solution is labeled
ONSCExp146-5
18:10 Water/glycol bath set to 40C.
18:35 Water/glycol bath temperate now at 40C, placed the vials in the bath.
21:07 Changed the temperature setting of the bath to 25C.
2009-11-10
13:20 Removed the samples from the bath at 25C. The vials were centrifuged.
14:00 Separated the ~100uL supernatant from the residues in to separate one dram vials containing DMSOd6 (700uL). The supernatant solution corresponding to the parent solution were labeled ONSCExp147-1A, ONSCExp147-2A, ONSCExp147-3A, ONSCExp147-4A and ONSCExp147-5A
17:00 Obtained HNMR of the solutions.